What does Cialis do for erectile dysfunction treatment?

Each man risks suffering from erectile dysfunction sooner or later. It is just a matter of time. It is always better not to wait till you have the first symptoms of such horrible diagnose for men as erectile dysfunction, which is inability to achieve and maintain an erection, which is necessary for sexual intercourse. However, there are no reasons to be in despair as there is an effective remedy to solve such problems. The drug Cialis based on Tadalafil is exactly what you need in case you experience any kind of erection problems, including premature ejaculation, which is by the way one of the first signs of ED.

What is the mechanism of Cialis action?

One of the most popular drugs that increase the potency of men is Cialis.

These pills successfully eliminate symptoms of sexual disorders, restore and enhance erections, improve the quality of sex and prolong it. Сialis refers to analogs of the world famous Viagra, but surpasses it in terms of duration of the action. The effect of Cialis pill is maintained for a half day or even more. Some men have the effect of the drug during 36 hours. Therefore, there is no equal drugs in the maintenance of an erection as Cialis shows the best possible results.

Cialis is an effective, reversible inhibitor selectively acting on phosphodiesterase 5 (PDE5). The central role in the erection is played by relaxation of smooth muscle cells of the corpus cavernosum of the penis, which locally initiated by acetylcholine and nitric oxide, as well as other physiological agents.

Acetylcholine is produced by neurons of the parasympathetic nervous system and nitric oxide is released by non-adrenergic non-cholinergic neurons and endothelial cells. The final effect is the suppression state of the sympathetic nervous system stimulation or alpha stimulation, which causes contraction of the smooth muscle cells. Both guanosine monophosphate (cGMP) and PDE5 play an important role for a normal erection. cGMP causes the expansion of the arteries, causing blood flow to the erectile tissues.

Blood vessels in the cavernous bodies fill with blood, which causes a decrease in the outflow of blood from the penis and creating a blood pressure gradient – an erection takes place. Enzyme PDE5 causes a decrease in the level of cGMP and terminates an erection.

Cialis inhibits the action of PDE5, thus delaying the decrease in the level of cGMP. As a result, the level of cGMP in the cavernous bodies allows men with erectile dysfunction have a normal erection.

Pharmacokinetics

 

  • Cialis Absorption

After oral administration Tadalafil is rapidly absorbed. The average maximum concentration (Cmax) in plasma is reached within 2 hours after administration. The rate and extent of absorption of tadalafil don’t dependent on food intake, so the drug Cialis may be taken without regard to mealtime. Hours (morning or evening) had no clinically significant effect on the rate and extent of absorption. The pharmacokinetics of tadalafil in patients with erectile dysfunction is similar to pharmacokinetics in men without erectile dysfunction.

  • Cialis Distribution

The average volume of distribution is around 63 liters suggesting that tadalafil is distributed in body tissues. At therapeutic concentrations, 94% of tadalafil in plasma is associated with proteins. Protein binding does not change with impaired renal function.

In healthy persons less than 0.0005% of the administered dose was found in semen.

  • Metabolism

Tadalafil is mainly metabolized with participation of cytochrome P450 isoenzyme CYP3A4. The major circulating metabolite is metilkateholglyukuronid. This metabolite is at least 13,000 times less active against PDE5 than tadalafil. Consequently, the concentration of this metabolite is not clinically significant.

  • Excretion

In healthy individuals the average clearance of tadalafil ingestion is 2,5 l / h, and the average half-life – 17.5 hours. Tadalafil is excreted mainly in the form of inactive metabolites, mainly in the feces (about 61% of the dose) and to a lesser extent in urine (about 36% of the dose).

How to take Cialis?

Many men who have faced the problem of sexual disorders are interested in how to take Cialis. After all, if used improperly, its effectiveness may be reduced, as well as increased doses may lead to the risk of adverse reactions.

Cialis is intended to be administered orally.  The maximum recommended dose of Cialis is 20 mg, which is prescribed to almost each patient suffering from erectile dysfunction. In any case it is better to consult your doctor in case you have doubts concerning the most effective dose for your health condition. Or you can adjust it starting with the smaller dose and increasing it gradually, choosing the best one for you.

Dosage of Cialis depending on how active you are

  • Regular sexual life: If men who have regular sexual life suffer from the mild erectile dysfunction, Cialis can be taken once a day for ¼ tablet – 5 mg. The drug is recommended to wash down at the same time every day regardless of the food intake and sexual activity. Expediency of the regular daily use should be periodically evaluated by the attending physician.
  • Not more than once per week: In disorders of erection in men who have sex not more than 1 time per week, Cialis should be used only before the planned sexual intercourse. The single dose in this case should be 20 mg. Remember that the maximum recommended frequency of admission – once per day as overdose may lead to some side effects.

With the development of impotence medication also should be used immediately 40-50 minutes before the expected intimacy. Cialis is taken before anticipated sexual activity, regardless of the meal, which is very convenient. The drug should be taken at least 16 minutes prior to the planned sexual activity.

Patients may carry an attempt to have sexual intercourse at any time within 36 hours after taking the drug. Cialis is the only one drug, which is able to provide men with such long-lasting effect.