Which dose of Cialis will be optimal for successful intercourse?

Optimal dosage 20 mg Cialis. Cialis is a patented drug, which is successfully used for the treatment of erectile dysfunction and has already helped a lot of men who are experiencing problems with potency to get the desired results. It is not difficult to improve your sexual life using such efficient drug as Cialis based on Tadalafil.

GET CIALIS & TREAT Erectile Dysfunction!

Nowadays there are a great number of producers who offer drugs with the similar effect. However, Cialis is one of the best due to the great amount of advantages it can offer its patients with different stage of erectile dysfunction. In order to get the best possible results it is necessary to take Cialis being aware of some important points. One of which is the optimal dosage, which can influence the effect you will get. Let’s consider how to take Cialis to avoid any side effects and succeed from its administration.

Which ingredients does Cialis tablet include?

Each tablet of Cialis drug consists of the following components:

  • Active substance: Tadalafil – 2.5 / 5/20 mg;
  • Auxiliary components: giproloza (hydroxypropylcellulose), lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, magnesium stearate; film coating: triacetin, hypromellose, lactose monohydrate, titanium dioxide, red iron oxide (2.5 mg tablet), yellow iron oxide.

The dosage regimen of the drug Cialis:

Cialis drug works with the help of relaxing smooth muscles of arteries, thereby enhancing blood flow to the tissues of the penis and increasing the likelihood of achieving and maintaining an erection, which will be sufficient for the successful sexual intercourse. You should remember that it is ineffective in the absence of sexual stimulation.

Middle-aged men are encouraged to take Cialis in the dosage of 20 mg. It is recommended to take Cialis at least 16 minutes prior to the anticipated sexual activity, regardless of the mealtime, which is one of its benefits compared to other ED treatment drugs. Patients can perform attempt of an intercourse any time within 36 hours after dosing in order to set the optimal response time to the drug.

The maximum recommended frequency of reception – once per day. Elderly men don’t need to adjust special dose regimen. Recommendations for receiving the drug for middle-aged men are also applicable to elderly patients.

Patients with impaired renal function (creatinine clearance> = 30 ml / min) and liver diseases don’t require specific dose adjustment as well.

Dosage of Cialis and frequency of your sexual activity

Is there any connection between the number of sexual intercourses you have per week and the Cialis dosage? Yes, there is the recommended dosing regimen, which is based exactly on how often you plan to have intimacy with your partner:

  • Frequent sexual activity (> 2 times per week) up to 5 mg per day for 1 reception, at one and the same time; depending on individual tolerability of the drug it is possible to reduce the daily dose to about 2.5 mg;
  • Infrequent sexual activity (<2 times per week): 20 mg per/1 administration, just before the planned sexual intercourse.

What will happen if you take the larger dose?

After taking Cialis at a dose of 500 mg / day healthy volunteers and patients with erectile dysfunction who used Cialis repeatedly 100 mg / day didn’t report any additional adverse effects, besides those which are possible in the use of the lower doses. In any case, it is recommended to inform your doctor about the overdose and conduct standard symptomatic therapy in case your healthcare specialist considers it to be necessary.

How does Cialis interact with other drugs?

The influence of other drugs on Cialis:

The drug Cialis is mainly metabolized by CYP3A4 enzyme. Selective CYP3A4 inhibitor ketoconazole increases the AUC by 107% and rifampicin reduces it by 88%. Despite the fact that the specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir as well as inhibitors of CYP3A4, such as itraconazole, and erythromycin are able to enhance the action of Cialis.

At the same time taking an antacid (magnesium hydroxide / aluminum hydroxide) together with Cialis reduces the rate of absorption of the latter without changing its AUC. Increase of gastric pH as a result of receiving blocker nizatidine histamine H2-receptors has no effect on the pharmacokinetics of Cialis based on Tadalafil.

Effect of the drug Cialis on other drugs:

  • Cialis enhances the hypotensive effect of nitrates due to the additive effect of nitrates and tadalafil on the metabolism of nitric oxide and cGMP. Therefore, the appointment of Cialis is contraindicated during treatment with nitrates.
  • Cialis has no clinically significant effect on the clearance of drugs that are metabolized with participation of cytochrome P450 isoenzymes. Studies have confirmed that Tadalafil does not inhibit or induce isozymes of CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9.
  • Cialis has no clinically significant effect on the pharmacokinetics of S-and R-warfarin. Tadalafil does not affect the action of warfarin on prothrombin time.
  • Cialis does not increase the duration of bleeding on the background of acetylsalicylic acid.
  • Cialis does not show a clinically significant interaction with the major classes of antihypertensive agents including calcium channel blockers (amlodipine), ACE inhibitors (enalapril), beta blockers (metoprolol), alpha-blockers, thiazide diuretics (bendoflyuazid), angiotensin II receptor blockers, which are used at varying doses alone or in some combination.
  • There were no differences in adverse events in patients taking Cialis with or without antihypertensive drugs.
  • There was no effect of a single dose of the drug Cialis on the concentration of ethanol in the blood, the effect of ethanol on cognitive function and blood pressure. Furthermore, no changes were observed on blood concentration in 3 hours after administration in combination with ethanol.